世界的権威のアーサー・コーンバーグ教授が、

その輝かしいキャリアの最後に追い求めたポリリン酸の研究は、

教授の遺志を継ぎ、今こうして日本で実を結びつつあります。

しかし、ポリリン酸の可能性はまだまだ計り知れません。

近年、ようやくポリリン酸の国際研究学会が立ち上がり、

世界中の学者が研究活動を進める土壌が整ったばかりです。

リジェンティス社は「EXポリリン酸®」を製造する世界唯一の企業として、

研究を進める世界中の大学や研究機関に無償で素材を提供し、

EXポリリン酸®のさらなる機能究明に向けた研究を様々な機関と共同で

続けております。

分割ポリリン酸®

スーパーポリリンホワイトニング

「EXポリリン酸®に関する代表的な論文・書籍」

Articles
T. Shiba, Inorganic polyphosphate and its chain length dependency in periodontal tissue regeneration including bone remodeling and teeth whitening., in Chapter 10 of Inorganic Polyphosphates in Eukaryotic Cells., T. Kulakovskaya, E. Pavlov, EN. Dedkova Eds. (2016).
LC. Wijeyewickrema, E. Lameignere, RC. Duncan, T. Shiba, RJ. Travers, PR. Kapopara, VL. Stephanie, H. Kim, JH. Morrissey, RN. Pike, EM. Conway, Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor., Blood, 128, 1766-1776 (2016).
PR. Angelova, BK. Agrawalla, PA. Elustondo, J. Gordon, T. Shiba, AY. Abramov, YT. Chang, EV. Pavlov, In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8., ACS Chem. Biol., 9, 2101-2110 (2014).
K. Doi, T. Kubo, R. Takeshita, S. Kajihara, S. Kato, Y. Kawazoe, T. Shiba, Y. Akagawa, Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: An animal study., Dent. Mater. J., 33, 179-186 (2014).
M. Koyasu, T. Shiba, Y. Kawazoe, A, Manabe, T. Miyazaki, Ultraphosphate, a potent stain control agent that is effective for both stain removal and prevention of stain deposition., Dent. Mater. J., 33, 1-9 (2014).
K. Tsutsumi, N. Saito, Y. Kawazoe, H-K. Ooi, T. Shiba, Morphogenetic study on the maturation of osteoblastic cell as induced by inorganic polyphosphate., PLOS ONE, 9, issue 2, e86834 (2014).
K. Harada, H. Itoh, Y. Kawazoe, S. Miyazaki, K. Doi, T. Kubo, Y. Akagawa, T. Shiba, Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts., PLOS ONE, 8, issue 11, e78612 (2013).
K. Harada, T. Shiba, K. Doi, K. Morita, T. Kubo, Y. Makihara, A. Piattelli, Y. Akagawa, Inorganic polyphosphate suppreses lipopolysaccharide-induced inducible nitric oxide synthase (iNOS) expression in macrophages., PLOS ONE, 8, issue 9, e74650 (2013).
N. Sun, H. Zou, L. Yang, K. Morita, P. Gong, T. Shiba, Y. Akagawa, Q. Yuan, Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway., Biochem. Biophys. Res. Com., 428, 298-302 (2012).
D. Morimoto, T. Tomita, S. Kuroda, C. Higuchi, S. Kato, T. Shiba, H. Nakagami, R. Morishita, H. Yoshikawa, Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells., J. Bone Miner. Metab., 28, 418-423 (2010).
M. Yamaoka, M. Ishizuka, K. Ishihama, M. Takahashi, M. Takahashi, H. Yamada, Y. Teramoto, K. Yasuda, T. Shiba, T. Uematsu, K. Furusawa, Bone formation without lamina dura in the middle-aged and elderly: possible dependence on enamel., Clinical Interventions in Aging, 5, 37-43 (2010).
K. Morita, K. Doi, T. Kubo, R. Takeshita, S. Kato, T. Shiba, Y. Akgagawa, Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite., Acta Biomaterialia, 6, 2808-2815 (2010).
Q. Yuan, T. Kubo, K. Doi, K. Morita, R. Takeshita, S. Katoh, T. Shiba, P. Gong, Y. Akagawa, Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration., Acta Biomaterialia, 5, 1716-1724 (2009).
Y. Kawazoe, S. Katoh, Y. Onodera, T. Kohgo, M. Shindoh, T. Shiba, Activation of the FGF signaling pathway and subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate., Int. J. Biol. Sci., 4, 37-47 (2008).
M. Yamaoka, T. Uematsu, T. Shiba, T. Matsuura, Y. Ono, M. Ishizuka, H. Naramoto, M. Takahashi, M. Sugiura-Tomita, K. Iguchi, S. Yamashita, K. Furusawa, Effect of inorganic polyphosphate in periodontitis in the elderly., Gerodontology., 25, 10-17 (2008).
Y. Hacchou, T. Uematsu, O. Ueda, Y. Usui, S. Uematsu, M. Takahashi, T. Uchihashi, Y. Kawazoe, T. Shiba, S. Kurihara, M. Yamaoka, K. Furusawa., Inorganic polyphosphate: a possible stimulant of bone formation., J. Dent. Res., 86, 893-897 (2007).
P. McInerney, T. Mizutani, T. Shiba, Inorganic polyphosphate interacts with ribosomes and promotes translation fidelity in vitro and in vivo. Mol. Microbiol. 60, 438-447 (2006).
H. Itoh, Y. Kawazoe, T. Shiba, Enhancement of protein synthesis by an inorganic polyphosphate in an E. coli cell-free system., J. Microbiol. Methods. 64, 241-249 (2006).
H. Zhang, N. N. Rao., T. Shiba, A. Kornberg, Inorganic polyphosphate in the social life of Myxococcus xanthus: Motility, development, and predation., Proc. Natl. Acad. Sci. USA 102, 13416-13420 (2005).
T. Shiba, H. Itoh, A. Kameda, Y. Kawazoe, K. Kobayashi, T. Noguchi, Polyphosphate:AMP phosphotransferase as a polyphosphate dependent nucleoside monophosphate kinase in Acinetobacter johnsonii 210A., J. Bacteriol., 187, 1859-1865 (2005).
H. Itoh and T. Shiba, Polyphosphate synthetic activity of polyphosphate:AMP phosphotransferase in Acinetobacter johnsonii 210A., J. Bacteriol. 186, 5178-5181 (2004).
Y. Kawazoe, T. Shiba, R. Nakamura, A. Mizuno, K. Tsutsumi, T. Uematsu, M. Yamaoka, M. Shindoh, T. Kohgo, Induction of calcification in MC3T3-E1 cells by inorganic polyphosphate., J. Dent. Res. 83, 613-618 (2004).
T. Shiba, Y. Takahashi, T. Uematsu, Y. Kawazoe, K. Ooi, K. Nasu, H. Itoh, H. Tanaka, M. Yamaoka, M. Shindoh, T. Kohgo, Effect of Inorganic Polyphosphate on Periodontal Regeneration., Key Engineering Materials, 254-256, 1119-1122 (2004).
T. Shiba, D. Nishimura, Y. Kawazoe, Y. Onodera, K. Tsutsumi, R. Nakamura, M. Ohshiro, Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate., J. Biol. Chem. 278, 26788-26792 (2003).
K. Ishige, T. Hashimoto, T. Shiba, T. Noguchi, Novel method for enzymatic synthesis of CMP-NeuAc., Biosci. Biotechnol. Biochem., 65, 1736-1740 (2001).
A. Kameda, T. Shiba, Y. Kawazoe, Y. Satoh, Y. Ihara, K. Ishige, T. Noguchi, A novel regeneration system using polyphsophate-AMP phosphotransferase and polyphosphate kinase., J. Biosci. Biotechnol. 9, 557-563 (2001).
K, Tsutsumi, M. Munekata, T. Shiba, Involvement of inorganic polyphosphate in expression of SOS genes., Biochim. Biophys. Acta., 1493, 73-81 (2000).
T. Miyake, T. Shiba, A. Kameda, Y. Ihara, M. Munekata, K. Ishige, T. Noguchi, The gene for exopolyphosphatase of Pseudomonas aeruginosa. DNA Research, 6, 103-108 (1999).
T. Noguchi, T. Shiba, Use of Escherichia coli polyphosphate kinase for oligosaccharide synthesis., Biosci. Biotechnol. Biochem., 62, 1594-1596 (1998).
K. Ishige, T. Shiba, T. Noguchi, The polyphosphate kinase gene of Pseudomonas aeruginosa. DNA research, 5, 157-162 (1998).
T. Shiba, K. Tsutsumi, H. Yano, Y. Ihara, A. Kameda, T. Kan, H, Takahashi, M. Munekata, N. N. Rao, A. Kornberg, Inorganic polyphosphate and the induction of rpoS expression., Proc. Natl. Acad. Sci. USA 94, 15146-15152 (1997).
H. Wurst, T. Shiba, A. Kornberg, The gene for a major exopolyphosphatase of Saccharomyces cerevisiae., J. Bacteriol. 177,898-906 (1995).